Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells

Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus : potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells

The integrity of the Ras/Raf/mitogen-activated protein kinase (MAPK) cascade is critical for maintenance of T cell tolerance, a process that fails in patients with systemic lupus erythematosus (SLE). In this study we have examined the activity of mitogen-activated protein kinases ERK-1 and ERK-2 in...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 106(2003), 1 vom: 01. Jan., Seite 41-9
1. Verfasser: Cedeño, Samandhy (VerfasserIn)
Weitere Verfasser: Cifarelli, Domenico F, Blasini, Ana M, Paris, Magdalena, Placeres, Fabiola, Alonso, Guillermina, Rodriguez, Martin A
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Adaptor Proteins, Signal Transducing GRB2 Adaptor Protein GRB2 protein, human Proteins Transcription Factor AP-1 ras Guanine Nucleotide Exchange Factors Mitogen-Activated Protein Kinase 1 EC 2.7.11.24 mehr... Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases