During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities

During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities

In the NOD mouse model of type 1 diabetes, major histocompatibilitycomplex (MHC) class I-restricted CD8(+) T cells are essential for disease development. However, the extent of diversity of their antigenic specificities during early pathogenesis remains unclear. An insulin-derived peptide was recent...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 105(2002), 3 vom: 17. Dez., Seite 332-41
1. Verfasser: DiLorenzo, Teresa P (VerfasserIn)
Weitere Verfasser: Lieberman, Scott M, Takaki, Toshiyuki, Honda, Shinichiro, Chapman, Harold D, Santamaria, Pere, Serreze, David V, Nathenson, Stanley G
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Epitopes Histocompatibility Antigens Class I Insulin