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01000caa a22002652c 4500 |
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NLM122820274 |
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DE-627 |
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20250203165630.0 |
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tu |
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231222s2002 xx ||||| 00| ||eng c |
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|a pubmed25n0410.xml
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|a (DE-627)NLM122820274
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|a (NLM)12498808
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Heltzer, Meredith
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Diminished T cell numbers in patients with chronic granulomatous disease
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| 264 |
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1 |
|c 2002
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.02.2003
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| 500 |
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|a Date Revised 06.11.2019
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Chronic granulomatous disease is a neutrophil disorder in which phagocytic cells fail to produce a respiratory burst. Five genetic types of chronic granulomatous disease have been described and in each case the clinical manifestations relate to the inability to effectively kill catalase-positive organisms. It is classically described as a pure disorder of intracellular killing, with preservation of other aspects of phagocytic function such as migration and phagocytosis and normal function of nonmyeloid cells. This article describes a heretofore unrecognized feature of chronic granulomatous disease. Fifty-three patients with chronic granulomatous disease and 42 age-matched controls were studied by flow cytometry. Total T cell numbers and CD4 and CD8 T cell numbers were compared between patients and controls. Patients with chronic granulomatous disease had diminished T cell numbers compared to controls after 3 years of age. The difference increased with age. It is not known whether diminished T cell numbers influence the susceptibility to infections in these patients, but T cell effects could represent a significant cofactor for infection
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| 650 |
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|a Comparative Study
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Jawad, Abbas F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rae, Julie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Curnutte, John T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sullivan, Kathleen E
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 105(2002), 3 vom: 17. Dez., Seite 273-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:105
|g year:2002
|g number:3
|g day:17
|g month:12
|g pages:273-8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 105
|j 2002
|e 3
|b 17
|c 12
|h 273-8
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