SDF-1alpha regulates HIV-1-gp120-induced changes in CD79b surface expression and Ig production in activated human B cells

SDF-1alpha regulates HIV-1-gp120-induced changes in CD79b surface expression and Ig production in activated human B cells

Binding of HIV-1 glycoprotein (gp120) to activated B cells of HIV-infected and HIV-uninfected subjects induces increased cell proliferation, cAMP generation, immunoglobulin (Ig) production and downregulation of the invariant chain, CD79b, of the B-cell receptor. We present evidence that the stromal...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 105(2002), 2 vom: 01. Nov., Seite 208-14
1. Verfasser: Nance, Christina L (VerfasserIn)
Weitere Verfasser: Shearer, William T
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Non-programmatic Anti-HIV Agents Antigens, CD CD79 Antigens CD79B protein, human CXCL12 protein, human Chemokine CXCL12 mehr... Chemokines, CXC HIV Envelope Protein gp120 Immunoglobulins Receptors, CXCR4