Production of antigen-specific human monoclonal antibodies comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci

Production of antigen-specific human monoclonal antibodies : comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci

Here we compare human monoclonal antibody (MAb) production from mouse strains that carry disruptions of their endogenous mouse IgH/IgK loci and harbor human IgM + Igkappa(BABkappa) or human IgM + Igkappa + IgA transloci (BABkappa,lambda). We found that whereas both strains proved effective for the i...

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Veröffentlicht in:BioTechniques. - 1991. - 33(2002), 3 vom: 11. Sept., Seite 680, 682, 684 passim
1. Verfasser: Magadán, S (VerfasserIn)
Weitere Verfasser: Valladares, M, Suarez, E, Sanjuán, I, Molina, A, Ayling, C, Davies, S L, Zou, X, Williams, G T, Neuberger, M S, Brüggemann, M, Gambón, F, Diaz-Espada, F, González-Fernandez, A
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Comparative Study Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Immunoglobulin M Immunoglobulin kappa-Chains