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NLM120758970 |
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DE-627 |
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20250203112409.0 |
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tu |
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231222s2002 xx ||||| 00| ||eng c |
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|a pubmed25n0403.xml
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|a (DE-627)NLM120758970
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|a (NLM)12217336
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Gorczynski, Reginald M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Anti-CD200R ameliorates collagen-induced arthritis in mice
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| 264 |
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1 |
|c 2002
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 04.11.2002
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| 500 |
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|a Date Revised 06.11.2019
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Immunization of DBA/1 with 100 microg bovine collagen type II emulsified in Freund's adjuvant, followed by booster injection in incomplete adjuvant at 18 days, leads to development of arthritis in more than 70% of mice by 28 days postinjection. We have previously shown that the novel immunosuppressant molecule CD200Fc (linking an extracellular domain of CD200 with a murine IgG2a Fc region) can suppress induction of disease when given to mice from the time of collagen injection. This occurs in concert with a decrease in the serum levels of anti-collagen IgG ( approximately 50% reduction), with relatively more IgG2b and IgG3, decreased serum levels of TNFalpha and IFN-gamma, and decreased production of those same cytokines after restimulation of lymphocytes in vitro with collagen. Since CD200 induces suppression following engagement of a receptor (CD200R), known to be expressed on, among other cells, macrophages, we investigated whether infusion of anti-CD200R and/or CD200Fc would ameliorate established disease in DBA mice, when injections were begun following collagen immunization. Our data indicate an arrest of disease following either treatment, with modification of a number of immune parameters (serum and lymphocyte cytokine production) consistent with a general role for CD200:CD200R interactions in the regulation of induction and/or expression of autoimmune disorders. When a higher dose (250 microg/mouse) of anti-CD200R was infused into a group of overtly arthritic mice, a significant ( approximately 50%) decrease in arthritic joint score occurred over the 4-week treatment period
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a Antigens, Surface
|2 NLM
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin Fc Fragments
|2 NLM
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| 650 |
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7 |
|a Receptors, Immunologic
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a Collagen
|2 NLM
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| 650 |
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7 |
|a 9007-34-5
|2 NLM
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| 650 |
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7 |
|a antigens, CD200
|2 NLM
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| 650 |
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7 |
|a UQ4V77A8VA
|2 NLM
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| 700 |
1 |
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|a Chen, Zhiqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Lydia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Kai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Jiang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 104(2002), 3 vom: 01. Sept., Seite 256-64
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:104
|g year:2002
|g number:3
|g day:01
|g month:09
|g pages:256-64
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 104
|j 2002
|e 3
|b 01
|c 09
|h 256-64
|