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20231227123118.0 |
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231222s2002 xx ||||| 00| ||eng c |
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|a pubmed24n1221.xml
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|a (DE-627)NLM120338882
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|a (NLM)12173304
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ismaili, Jamila
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Human gamma delta T cells induce dendritic cell maturation
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| 264 |
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1 |
|c 2002
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 28.08.2002
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|a Date Revised 13.12.2023
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a gamma delta T cells are known to be involved in the innate immune defenses against infectious microorganisms. Herein, we considered that gamma delta T cells could also influence adaptative immunity by interacting with dendritic cells (DC) in the early phase of the immune response. To investigate this hypothesis, gamma delta T cells isolated from the peripheral blood of healthy volunteers were cocultured with autologous monocyte-derived dendritic cells, which were subsequently analyzed for their expression of key surface molecules and for their production of IL-12. First, we found that gamma delta T cells induced the upregulation of HLA-DR, CD86, and CD83 on DC. This effect did not require cell to cell contact and could be blocked by a neutralizing anti-TNF antibody. We then observed that gamma delta T cells activated by the synthetic phosphoantigen bromohydrin pyrophosphate (BrHPP) induced the production of IL-12 (p40) and IL-12 (p70) by DC, an effect that involved IFN-gamma production. The relevance of this finding to DC function was demonstrated by the increased production of IFN-gamma by alloreactive T cells when stimulated in a mixed leucocyte reaction with DC preincubated with activated gamma delta T cells. We conclude that gamma delta T cell activation might result in DC maturation and thereby in enhanced alpha beta T cell responses
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a B7-2 Antigen
|2 NLM
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| 650 |
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|a CD86 protein, human
|2 NLM
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| 650 |
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|a Diphosphates
|2 NLM
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| 650 |
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7 |
|a HLA-DR Antigens
|2 NLM
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| 650 |
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7 |
|a Immunoglobulins
|2 NLM
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell, gamma-delta
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a bromohydrin pyrophosphate
|2 NLM
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| 650 |
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7 |
|a Interleukin-12
|2 NLM
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| 650 |
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7 |
|a 187348-17-0
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Olislagers, Véronique
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Poupot, Rémy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fournié, Jean-Jacques
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Goldman, Michel
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 103(2002), 3 Pt 1 vom: 22. Juni, Seite 296-302
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:103
|g year:2002
|g number:3 Pt 1
|g day:22
|g month:06
|g pages:296-302
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| 912 |
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 103
|j 2002
|e 3 Pt 1
|b 22
|c 06
|h 296-302
|