Elevated levels of serum macrophage migration inhibitory factor in patients with pulmonary tuberculosis

Macrophage migration inhibitory factor (MIF) was originally described as a T-cell-derived cytokine that inhibits the random migration of macrophages and promotes the delayed-type hypersensitivity reaction. MIF plays an important role in the regulation of the Th1/Th2 balance in inflammatory response....

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 104(2002), 2 vom: 06. Aug., Seite 123-7
1. Verfasser: Yamada, Gen (VerfasserIn)
Weitere Verfasser: Shijubo, Noriharu, Takagi-Takahashi, Yoko, Nishihira, Jun, Mizue, Yuka, Kikuchi, Kokichi, Abe, Shosaku
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Macrophage Migration-Inhibitory Factors Interferon-gamma 82115-62-6
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245 1 0 |a Elevated levels of serum macrophage migration inhibitory factor in patients with pulmonary tuberculosis 
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520 |a Macrophage migration inhibitory factor (MIF) was originally described as a T-cell-derived cytokine that inhibits the random migration of macrophages and promotes the delayed-type hypersensitivity reaction. MIF plays an important role in the regulation of the Th1/Th2 balance in inflammatory response. This study investigated serum levels of circulating MIF in patients with pulmonary tuberculosis. The levels of MIF in sera were measured by enzyme-linked immunosorbent assay in 34 patients with pulmonary tuberculosis (16 males and 18 females) and 30 healthy controls (15 males and 15 females). The mean levels of circulating MIF values were significantly higher in those with pulmonary tuberculosis (19.84 +/- 11.27 ng/ml; P < 0.0001) than in the healthy controls (4.38 +/- 1.34 ng/ml). Circulating MIF values significantly correlated with circulating interferon-gamma values (r = 0.537, P < 0.0001). Thus, MIF may play an important role in immune responses to human infection with Mycobacterium tuberculosis 
650 4 |a Comparative Study 
650 4 |a Journal Article 
650 7 |a Macrophage Migration-Inhibitory Factors  |2 NLM 
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650 7 |a 82115-62-6  |2 NLM 
700 1 |a Shijubo, Noriharu  |e verfasserin  |4 aut 
700 1 |a Takagi-Takahashi, Yoko  |e verfasserin  |4 aut 
700 1 |a Nishihira, Jun  |e verfasserin  |4 aut 
700 1 |a Mizue, Yuka  |e verfasserin  |4 aut 
700 1 |a Kikuchi, Kokichi  |e verfasserin  |4 aut 
700 1 |a Abe, Shosaku  |e verfasserin  |4 aut 
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