Diagnosis of chronic myelogenous leukemia in a dog using morphologic, cytochemical, and flow cytometric techniques

Chronic myelogenous leukemia was diagnosed in a 3.5-year-old neutered male Golden Retriever. The diagnosis was based on persistent leukocytosis (>73.0X10(3)/microliter), composed of a proportionate left shift to progranulocytes with no evidence of underlying inflammation, infection, or neoplasia....

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Veröffentlicht in:Veterinary clinical pathology. - 1990. - 30(2001), 1 vom: 23., Seite 19-24
1. Verfasser: Tarrant, Jacqueline M. (VerfasserIn)
Weitere Verfasser: Stokol, Tracy, Blue, Julia T., McDonough, Sean P., Farrell, Peter
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2001
Zugriff auf das übergeordnete Werk:Veterinary clinical pathology
Schlagworte:Journal Article
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520 |a Chronic myelogenous leukemia was diagnosed in a 3.5-year-old neutered male Golden Retriever. The diagnosis was based on persistent leukocytosis (>73.0X10(3)/microliter), composed of a proportionate left shift to progranulocytes with no evidence of underlying inflammation, infection, or neoplasia. Marked dysplasia was evident in neutrophils and platelets in peripheral blood. Bone marrow and splenic aspirates were dominated by mature and immature neutrophils with < 2% myeloblasts. Cytochemical and flow cytometric assays confirmed that cells in the peripheral blood and spleen were of committed neutrophil lineage. The dog responded initially to treatment with hydroxyurea, but developed acute undifferentiated leukemia approximately 83 days after initial presentation 
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700 1 |a Blue, Julia T.  |e verfasserin  |4 aut 
700 1 |a McDonough, Sean P.  |e verfasserin  |4 aut 
700 1 |a Farrell, Peter  |e verfasserin  |4 aut 
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