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|a pubmed25n0397.xml
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|a (NLM)12024320
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Burkhard, Mary Jo
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Evaluation of the erythroid regenerative response in two different models of experimentally induced iron deficiency anemia
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| 264 |
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|c 2001
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Revised 20.11.2019
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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| 520 |
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|a Anemia was induced in weanling Sprague Dawley rats either by feeding an iron-deficient diet or by chronic phlebotomy. The erythroid regenerative response was then evaluated before and after a hemolytic event, and results were compared with those of a third group of control nonphlebotomized rats fed an iron-replete diet. Diet and phlebotomy groups developed a similar degree of anemia (mean hemoglobin concentration 7.9 g/dL and 7.8 g/dL, respectively; controls, 13.9 g/dL) and hypoferremia (mean serum iron concentration 25.4 microgram/dL and 34.9 microgram/dL, respectively; controls, 222.0 microgram/dL). However, the anemia in diet rats was nonregenerative (reticulocyte count, 83.1 X 10(3) cells/microliter) and associated with bone marrow erythroid hypoplasia; whereas the anemia in phlebotomy rats was regenerative (reticulocyte count, 169.6 X 10(3) cells/microliter) and associated with bone marrow erythroid hyperplasia. Thrombocytosis was seen in diet rats (1,580 X 10(3) cells/microliter) but not phlebotomy rats (901 X 10(3) cells/microliter) when compared with controls (809 X 10(3) cells/microliter). To further evaluate the regenerative capability, phenylhydrazine (PHZ) was administered to induce hemolysis. Erythrocyte mass declined approximately 25% in all groups, including controls. The reticulocytosis (265.3 X 10(3) cells/microliter) seen in phlebotomy rats was earlier and significantly greater than that seen in either diet or control rats. Hemoglobin concentration returned to pre-PHZ concentrations (7.9 g/dL) in phlebotomy rats within 4 days posthemolysis. In diet rats, the maximal regenerative response (176.3 X 10(3) cells/microliter) was not seen until 8 days posthemolysis, and hemoglobin (7.5 g/dL) did not return to pre-PHZ concentrations during the 8-day study. In many aspects, the anemia seen following diet- or phlebotomy-induced iron deficiency was similar. However, the erythroid regenerative capability varied depending on the mechanism by which anemia was induced and furthermore altered the efficiency of hemoglobin production following a hemolytic event. These results suggest that the availability of iron in the diet may modulate the pathogenesis of iron deficiency anemia
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| 650 |
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|a Journal Article
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| 700 |
1 |
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|a Brown, Diane E.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McGrath, John P.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meador, Vince P.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mayle, Douglas A.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Keaton, M. Joni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hoffman, Wherly P.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zimmermann, John L.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abbott, David L.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Steven C.
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1990
|g 30(2001), 2 vom: 23., Seite 76-85
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
8 |
|g volume:30
|g year:2001
|g number:2
|g day:23
|g pages:76-85
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 30
|j 2001
|e 2
|b 23
|h 76-85
|