Modeling the effect of an external electric field on the velocity of spike propagation in a nerve fiber
The effect of an externally generated electric field on the propagation of action potentials is modeled, assuming the Hodgkin-Huxley equation for the voltage-dependent conductance of the membrane of a nerve fiber. With some simplifying assumptions, this conductance together with Maxwell's equat...
| Veröffentlicht in: | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. - 1993. - 60(1999), 5 Pt B vom: 30. Nov., Seite 5918-25 |
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| 1. Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1999
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| Zugriff auf das übergeordnete Werk: | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics |
| Schlagworte: | Journal Article Research Support, U.S. Gov't, P.H.S. |
| Zusammenfassung: | The effect of an externally generated electric field on the propagation of action potentials is modeled, assuming the Hodgkin-Huxley equation for the voltage-dependent conductance of the membrane of a nerve fiber. With some simplifying assumptions, this conductance together with Maxwell's equations leads to the Hodgkin-Huxley differential equations for propagation, modified by a term proportional to the gradient of the externally generated electric field component along the nerve fiber. Computer solution of these equations shows the influence of an electric field gradient on propagation velocity. When the electric field oscillates, voltage spikes starting later along a given axon advance or lag relative to earlier spikes, so the time between spikes at the receiving end differs from the time between spike originations. The amount that a low-frequency electric field modulates pulse timing at the end of a fiber relative to that at the beginning is estimated under several conditions |
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| Beschreibung: | Date Completed 26.08.2002 Date Revised 28.07.2019 published: Print Citation Status MEDLINE |
| ISSN: | 1063-651X |