Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis

Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis

Estrogen treatment has been found to have suppressive activity in several models of autoimmunity. To investigate the mechanism of 17 beta-estradiol (E2) suppression of experimental autoimmune encephalomyelitis, we evaluated E2 effects on TNF-alpha expression in the central nervous system (CNS) and s...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 102(2002), 3 vom: 22. März, Seite 275-82
Auteur principal: Ito, Atsushi (Auteur)
Autres auteurs: Buenafe, Abigail C, Matejuk, Agata, Zamora, Alex, Silverman, Marc, Dwyer, Jami, Vandenbark, Arthur A, Offner, Halina
Format: Article
Langue:English
Publié: 2002
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Glycoproteins Myelin-Oligodendrocyte Glycoprotein Nerve Tissue Proteins Peptide Fragments Tumor Necrosis Factor-alpha myelin oligodendrocyte glycoprotein (35-55) plus... Estradiol 4TI98Z838E