Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis

Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis

Estrogen treatment has been found to have suppressive activity in several models of autoimmunity. To investigate the mechanism of 17 beta-estradiol (E2) suppression of experimental autoimmune encephalomyelitis, we evaluated E2 effects on TNF-alpha expression in the central nervous system (CNS) and s...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 102(2002), 3 vom: 22. März, Seite 275-82
1. Verfasser: Ito, Atsushi (VerfasserIn)
Weitere Verfasser: Buenafe, Abigail C, Matejuk, Agata, Zamora, Alex, Silverman, Marc, Dwyer, Jami, Vandenbark, Arthur A, Offner, Halina
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Glycoproteins Myelin-Oligodendrocyte Glycoprotein Nerve Tissue Proteins Peptide Fragments Tumor Necrosis Factor-alpha myelin oligodendrocyte glycoprotein (35-55) mehr... Estradiol 4TI98Z838E