Analysis of monocyte chemotactic protein-1 production in different major histocompatability complex-restricted antigen presentation systems
Copyright 2001 Academic Press.
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 101(2001), 1 vom: 28. Okt., Seite 77-85 |
|---|---|
| Auteur principal: | |
| Autres auteurs: | , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2001
|
| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Chemokine CCL2 Histocompatibility Antigens Class II Isoantigens Concanavalin A 11028-71-0 |
| Résumé: | Copyright 2001 Academic Press. In the present study the production of the CC chemokine monocyte chemotactic protein-1 (MCP-1) in several MHC II-restricted antigen presentation systems was investigated in vitro. To assess which type of antigen-presenting cell (APC) influences MCP-1 production during antigen presentation, cultures enriched for different APC populations were prepared and MCP-1 production was determined. Our results showed that APCs that effectively induce a T cell response also produce elevated amounts of MCP-1. The MCP-1 production is highest in the memory-driven secondary response against a single antigen. Despite a massive T cell proliferation, low MCP-1 concentrations are found in Con A-induced cultures. These results suggest that T cell proliferation alone is not sufficient for MCP-1 production and that stimulation of the APC during the process of antigen presentation results in MCP-1 production. Based on our results and the literature, we propose a model for MCP-1 as an enhancer of the adaptive immune response |
|---|---|
| Description: | Date Completed 04.12.2001 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
| ISSN: | 1521-7035 |