T cell receptor Vbeta repertoire expression reflects gastric carcinoma progression
Copyright 2001 Academic Press.
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 101(2001), 1 vom: 28. Okt., Seite 3-7 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2001
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Case Reports Comparative Study Journal Article Research Support, Non-U.S. Gov't Complementarity Determining Regions RNA, Neoplasm Receptors, Antigen, T-Cell, alpha-beta |
| Résumé: | Copyright 2001 Academic Press. Analysis of TCR beta-chain complementarity-determining region size gives an indication of the T cell immune response. We examined CD4+ and CD8+ subgroups of T cells in the peripheral blood (PBL), benign gastric mucosa, and tumor (TIL) lymphocytes of 12 patients with primary gastric carcinomas of both intestinal and diffuse types. The average number of expanded clones in each compartment, expressed by the 24 families of the TCRVbeta repertoire, was analyzed according to tumor histological type, maximal invasive depth, and lymph node metastases. Fewer clones were expressed by the PBL in the cases with lymph node metastases than in those without (CD4+ P = 0.00017, CD8+ P = 0.016). Fewer CD8+ clones were expressed by the PBL in the cases with full thickness tumor infiltration than in those involving only the mucosa and submucosa (P = 0.05). The CD8+ TIL showed significantly fewer clones in the diffuse-type carcinoma than in the intestinal type (P = 0.046) |
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| Description: | Date Completed 04.12.2001 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
| ISSN: | 1521-7035 |