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231222s2001 xx ||||| 00| ||eng c |
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|a pubmed25n0381.xml
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|a (DE-627)NLM114117020
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|a (NLM)11513007
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|a DE-627
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|c DE-627
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|a eng
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|a Yoshida, S
|e verfasserin
|4 aut
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|a XANES spectroscopy of a single neuron from a patient with Parkinson's disease
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|c 2001
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 06.09.2001
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|a Date Revised 05.06.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a Chemical state of transition metals such as iron in a single neuron of the substantia nigra (SN) from a patient with Parkinson's disease (PD) was studied in this paper, using autopsy midbrain specimens including SN. Parkinson's disease is one of the major neurodegenerative diseases. The excessive accumulation of iron and its chemical states in SN neurons are related to the oxidative damage leading to neuronal cell death. X-ray absorption fine structure spectroscopy (XAFS) with SR micro beam (10 microm) was used to investigate the chemical state of iron in the SN neurons. X-ray absorption near-edge structure (XANES) spectroscopy results showed that the chemical state of iron in the neuromelanin granules within SN neurons changed from ferrous (Fe2+) to ferric (Fe3+) ion in the process of neuronal degeneration
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|a Journal Article
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|a Melanins
|2 NLM
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|a neuromelanin
|2 NLM
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|a Iron
|2 NLM
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|a E1UOL152H7
|2 NLM
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|a Ektessabi, A
|e verfasserin
|4 aut
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| 700 |
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|a Fujisawa, S
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1999
|g 8(2001), Pt 2 vom: 01. März, Seite 998-1000
|w (DE-627)NLM09824129X
|x 0909-0495
|7 nnns
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| 773 |
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|g volume:8
|g year:2001
|g number:Pt 2
|g day:01
|g month:03
|g pages:998-1000
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|a GBV_USEFLAG_A
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|a GBV_ILN_40
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|a GBV_ILN_350
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|a GBV_ILN_2005
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|a AR
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|d 8
|j 2001
|e Pt 2
|b 01
|c 03
|h 998-1000
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