Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage

Détails bibliographiques
Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 100(2001), 2 vom: 11. Aug., Seite 144-8
Auteur principal:	van der Vliet, H J (Auteur)
Autres auteurs:	von Blomberg, B M, Nishi, N, Reijm, M, Voskuyl, A E, van Bodegraven, A A, Polman, C H, Rustemeyer, T, Lips, P, van den Eertwegh, A J, Giaccone, G, Scheper, R J, Pinedo, H M
Format:	Article
Langue:	English
Publié:	2001
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, Non-U.S. Gov't Antigens, CD1 Immunoglobulin Variable Region Receptors, Antigen, T-Cell, alpha-beta

Description
Résumé:	Copyright 2001 Academic Press. Natural killer T (NKT) cells have been implicated as playing an important role in regulating immune responses. Defects in the NKT cell population were reported in animal autoimmune disease models and in distinct human autoimmune diseases. Here, we report that circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints, regardless of disease duration or activity. Remarkably, normal circulating V(alpha24+) Vbeta11+ NKT cell numbers were found in Graves disease and coeliac disease. Since earlier studies noted a rise in NKT cells in myasthenia gravis, the picture emerges in which a defective NKT cell population is associated with autoreactive tissue damage rather than with the propensity to develop autoimmune disease. The present data support the idea that therapies aiming at the in vivo expansion of regulatory NKT cells might help to control immune-mediated damage in autoimmune disease
Description:	Date Completed 23.08.2001 Date Revised 15.11.2006 published: Print Citation Status MEDLINE
ISSN:	1521-7035