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01000naa a22002652 4500 |
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NLM113186622 |
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DE-627 |
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20231222163343.0 |
| 007 |
tu |
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231222s2001 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0378.xml
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| 035 |
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|a (DE-627)NLM113186622
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| 035 |
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|a (NLM)11414749
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Alemán, M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
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| 264 |
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1 |
|c 2001
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 16.08.2001
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| 500 |
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|a Date Revised 30.11.2018
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2001 Academic Press.
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| 520 |
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|a Activation of peripheral blood neutrophils (PMN) was investigated in order to determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (FcgammaR) (FcgammaRI, FcgammaRII, and FcgammaRIIIB), CD66 (degranulation marker), and receptors for tumor necrosis factor-alpha (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide anion generation triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-alpha and IL-1beta production were evaluated. A high expression of TNF-R55, CD66, and FcgammaRIIIB and the appearance of FcgammaRI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-alpha and IL-1beta production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggests the possibility of a systemic inflammation that could modulate the inflammatory response
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigen-Antibody Complex
|2 NLM
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a Antigens, Differentiation
|2 NLM
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| 650 |
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7 |
|a CD66 antigens
|2 NLM
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| 650 |
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7 |
|a Cell Adhesion Molecules
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Interleukin-1
|2 NLM
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| 650 |
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7 |
|a Receptors, IgG
|2 NLM
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| 650 |
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7 |
|a Receptors, Tumor Necrosis Factor
|2 NLM
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| 650 |
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7 |
|a Receptors, Tumor Necrosis Factor, Type I
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Superoxides
|2 NLM
|
| 650 |
|
7 |
|a 11062-77-4
|2 NLM
|
| 650 |
|
7 |
|a N-Formylmethionine Leucyl-Phenylalanine
|2 NLM
|
| 650 |
|
7 |
|a 59880-97-6
|2 NLM
|
| 700 |
1 |
|
|a Beigier-Bompadre, M
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Borghetti, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de la Barrera, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abbate, E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Isturiz, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sasiain, M C
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 100(2001), 1 vom: 10. Juli, Seite 87-95
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:100
|g year:2001
|g number:1
|g day:10
|g month:07
|g pages:87-95
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 100
|j 2001
|e 1
|b 10
|c 07
|h 87-95
|