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01000naa a22002652 4500 |
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NLM113186584 |
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DE-627 |
| 005 |
20231222163343.0 |
| 007 |
tu |
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231222s2001 xx ||||| 00| ||eng c |
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5 |
2 |
|a pubmed24n0378.xml
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| 035 |
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|a (DE-627)NLM113186584
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| 035 |
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|a (NLM)11414745
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chehimi, J
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Cytokine and chemokine dysregulation in hyper-IgE syndrome
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| 264 |
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1 |
|c 2001
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 16.08.2001
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| 500 |
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|a Date Revised 19.10.2016
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2001 Academic Press.
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| 520 |
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|a Hyper-IgE syndrome is characterized by severe recurrent staphylococcal infections, eczema, bone abnormalities, and markedly elevated levels of immunoglobulin E (IgE). The genetic basis is not known and the central immunologic defect is largely undefined. Reduced neutrophil chemotaxis is often described, and variable T cell defects have been demonstrated in some patients. It has been hypothesized that hyper-IgE is associated with a Th1/Th2 imbalance. We wished to characterize cytokine and chemokine imbalances that might reflect the underlying disease process or reflect ongoing pathologic processes. Nine patients with hyper-IgE syndrome and six controls were studied. Radioimmunoassays, flow cytometry, and gene array analyses were performed to characterize cytokine and chemokine production. Hyper-IgE patients express more IL-12, while ENA-78, MCP-3, and eotaxin are markedly underexpressed. Underexpression of a set of chemokines could explain a number of features of hyper-IgE syndrome and may offer a new paradigm for the understanding of this disorder
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a CCL11 protein, human
|2 NLM
|
| 650 |
|
7 |
|a CCL7 protein, human
|2 NLM
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| 650 |
|
7 |
|a CXCL5 protein, human
|2 NLM
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| 650 |
|
7 |
|a Chemokine CCL11
|2 NLM
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| 650 |
|
7 |
|a Chemokine CCL7
|2 NLM
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| 650 |
|
7 |
|a Chemokine CXCL5
|2 NLM
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| 650 |
|
7 |
|a Chemokines
|2 NLM
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| 650 |
|
7 |
|a Chemokines, CC
|2 NLM
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| 650 |
|
7 |
|a Chemokines, CXC
|2 NLM
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| 650 |
|
7 |
|a Cytokines
|2 NLM
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| 650 |
|
7 |
|a DNA, Complementary
|2 NLM
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| 650 |
|
7 |
|a Interleukin-8
|2 NLM
|
| 650 |
|
7 |
|a Interleukins
|2 NLM
|
| 650 |
|
7 |
|a Monocyte Chemoattractant Proteins
|2 NLM
|
| 650 |
|
7 |
|a Phytohemagglutinins
|2 NLM
|
| 650 |
|
7 |
|a RNA, Messenger
|2 NLM
|
| 650 |
|
7 |
|a SPP1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Sialoglycoproteins
|2 NLM
|
| 650 |
|
7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
|
7 |
|a Osteopontin
|2 NLM
|
| 650 |
|
7 |
|a 106441-73-0
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-12
|2 NLM
|
| 650 |
|
7 |
|a 187348-17-0
|2 NLM
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| 650 |
|
7 |
|a Interferon-gamma
|2 NLM
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| 650 |
|
7 |
|a 82115-62-6
|2 NLM
|
| 650 |
|
7 |
|a Nicotinamide Phosphoribosyltransferase
|2 NLM
|
| 650 |
|
7 |
|a EC 2.4.2.12
|2 NLM
|
| 650 |
|
7 |
|a nicotinamide phosphoribosyltransferase, human
|2 NLM
|
| 650 |
|
7 |
|a EC 2.4.2.12
|2 NLM
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| 650 |
|
7 |
|a Receptor, trkA
|2 NLM
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| 650 |
|
7 |
|a EC 2.7.10.1
|2 NLM
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| 650 |
|
7 |
|a Tetradecanoylphorbol Acetate
|2 NLM
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| 650 |
|
7 |
|a NI40JAQ945
|2 NLM
|
| 700 |
1 |
|
|a Elder, M
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Greene, J
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Noroski, L
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Stiehm, E R
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Winkelstein, J A
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Sullivan, K E
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 100(2001), 1 vom: 10. Juli, Seite 49-56
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:100
|g year:2001
|g number:1
|g day:10
|g month:07
|g pages:49-56
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| 912 |
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|a GBV_USEFLAG_A
|
| 912 |
|
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|a SYSFLAG_A
|
| 912 |
|
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|a GBV_NLM
|
| 912 |
|
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|a GBV_ILN_11
|
| 912 |
|
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|a GBV_ILN_24
|
| 912 |
|
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|a GBV_ILN_350
|
| 951 |
|
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|a AR
|
| 952 |
|
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|d 100
|j 2001
|e 1
|b 10
|c 07
|h 49-56
|