Azodicarbonamide as a new T cell immunosuppressant synergy with cyclosporin A

Azodicarbonamide as a new T cell immunosuppressant : synergy with cyclosporin A

Copyright 2001 Academic Press.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 100(2001), 1 vom: 10. Juli, Seite 24-30
1. Verfasser: Tassignon, J (VerfasserIn)
Weitere Verfasser: Vandevelde, M, Goldman, M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2001
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Antigens, Differentiation, T-Lymphocyte Azo Compounds CD69 antigen Calcineurin Inhibitors DNA-Binding Proteins Immunosuppressive Agents Interleukin-2 mehr... Ionophores Lectins, C-Type NFATC Transcription Factors Nuclear Proteins Receptors, Interleukin-2 Transcription Factors Calcimycin 37H9VM9WZL azodicarbonamide 56Z28B9C8O Cyclosporine 83HN0GTJ6D
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245 1 0 |a Azodicarbonamide as a new T cell immunosuppressant  |b synergy with cyclosporin A 
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500 |a Date Revised 08.12.2020 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Copyright 2001 Academic Press. 
520 |a We recently demonstrated that azodicarbonamide is an immunosuppressive compound that inhibits calcium mobilization in T lymphocytes. In this study, we show that azodicarbonamide prevents the progression of human CD4+ T lymphocytes into the G1 phase of the cell cycle, inhibits their blastogenesis, down-regulates their membrane expression of CD25 and CD69, and decreases their transcription of cytokine genes. Addition of the calcium ionophore A23187 completely restores T cell proliferation in the presence of azodicarbonamide. Furthermore, azodicarbonamide synergizes with cyclosporin A to inhibit CD4+ T cell proliferation. In conclusion, the immunosuppressive action of azodicarbonamide is mainly related to its effect on the calcium mobilization machinery and is synergistic with that of calcineurin inhibitors 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a Antigens, Differentiation, T-Lymphocyte  |2 NLM 
650 7 |a Azo Compounds  |2 NLM 
650 7 |a CD69 antigen  |2 NLM 
650 7 |a Calcineurin Inhibitors  |2 NLM 
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650 7 |a Ionophores  |2 NLM 
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650 7 |a Nuclear Proteins  |2 NLM 
650 7 |a Receptors, Interleukin-2  |2 NLM 
650 7 |a Transcription Factors  |2 NLM 
650 7 |a Calcimycin  |2 NLM 
650 7 |a 37H9VM9WZL  |2 NLM 
650 7 |a azodicarbonamide  |2 NLM 
650 7 |a 56Z28B9C8O  |2 NLM 
650 7 |a Cyclosporine  |2 NLM 
650 7 |a 83HN0GTJ6D  |2 NLM 
700 1 |a Vandevelde, M  |e verfasserin  |4 aut 
700 1 |a Goldman, M  |e verfasserin  |4 aut 
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