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01000naa a22002652 4500 |
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NLM112377297 |
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DE-627 |
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20231222161625.0 |
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231222s2001 xx ||||| 00| ||jpn c |
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|a pubmed24n0375.xml
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|a (NLM)11329957
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a jpn
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| 100 |
1 |
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|a Iwaki, H
|e verfasserin
|4 aut
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| 245 |
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|a Predictive value of prostate specific antigen density in the detection of prostate cancer in patients with elevated prostate specific antigen levels and normal digital rectal findings or stage A prostate cancer
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|c 2001
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
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|2 rdacarrier
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|a Date Completed 17.05.2001
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|a Date Revised 15.11.2006
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|a published: Print
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|a Citation Status MEDLINE
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|a We compared the usefulness of PSA and PSA density (PSAD) in diagnosing prostate cancer in 102 men who had a PSA value higher than 4.0 ng/ml and normal digital rectal examination and who had undergone transrectal ultrasonography-guided systematic sextant biopsies of the prostate between August 1996 and October 1999. In addition, for a group of 53 patients who underwent retropubic simple prostatectomy, PSA, PSAD and PSA transition zone (PSA-TZ) examination results for those with stage A prostate cancer were compared with the results for those with benign prostatic hyperplasia (BPH). Of the former 102 men, 20 (19.6%) had prostate cancer. There was no significant difference in mean PSA level between patients with negative and those with positive biopsy results (mean 9.3 and 11.8, respectively, p = 0.295), but the mean PSAD of patients with positive biopsy results was significantly higher than that of those with negative results (mean 0.55 and 0.29, respectively, p = 0.0007). Of the 53 men who underwent retropubic simple prostatectomy, 10 (18.9%) were diagnosed with stage A prostate cancer. There was no significant difference in mean PSA, PSAD and PSA-TZ examination results between patients with BPH and those with stage A prostate cancer. For all 102 patients and for 71 patients with PSA levels of 4.1-10.0 ng/ml, a PSAD cutoff value of 0.1 reduced the number of biopsies 15.7% (16 of 102 cases), and 22.5% (16 of 71 cases), respectively. These results suggest that by measurement of PSAD some patients with benign disease could be spared a biopsy which would have been performed based on PSA results alone
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| 650 |
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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|a Prostate-Specific Antigen
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.77
|2 NLM
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| 700 |
1 |
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|a Kajita, Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shimizu, Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamauchi, T
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 47(2001), 3 vom: 15. März, Seite 169-74
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
8 |
|g volume:47
|g year:2001
|g number:3
|g day:15
|g month:03
|g pages:169-74
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| 952 |
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|d 47
|j 2001
|e 3
|b 15
|c 03
|h 169-74
|