A randomized comparative study assessing once versus twice a day treatment of benign prostatic hyperplasia with terazosin

We compared the efficacy of once a day administration of terazosin hydrochloride with that of twice a day administration for benign prostatic hyperplasia (BPH) patients. Forty-two patients with BPH were randomly assigned to receive a maximum dose of 2 mg terazosin either once (n = 21) or twice (n =...

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Bibliographische Detailangaben
Veröffentlicht in:	Hinyokika kiyo. Acta urologica Japonica. - 1962. - 47(2001), 2 vom: 01. Feb., Seite 77-81
1. Verfasser:	Suzuki, H (VerfasserIn)
Weitere Verfasser:	Ohnishi, T, Ikemoto, I, Ohishi, Y, Suzuki, Y, Yamazaki, H
Format:	Aufsatz
Sprache:	Japanese
Veröffentlicht:	2001
Zugriff auf das übergeordnete Werk:	Hinyokika kiyo. Acta urologica Japonica
Schlagworte:	Clinical Trial English Abstract Journal Article Multicenter Study Randomized Controlled Trial Adrenergic alpha-Antagonists Terazosin 8L5014XET7 Prazosin XM03YJ541D

Beschreibung
Zusammenfassung:	We compared the efficacy of once a day administration of terazosin hydrochloride with that of twice a day administration for benign prostatic hyperplasia (BPH) patients. Forty-two patients with BPH were randomly assigned to receive a maximum dose of 2 mg terazosin either once (n = 21) or twice (n = 21) a day. International prostate symptom score (IPSS), uroflowmetry and side effect profile were determined before and 4 weeks after randomization. Both groups were similar with respect to patient age, baseline IPSS and prostate volume. After 4 weeks of treatment with terazosin, significant improvement in IPSS, maximum flow rate and mean flow rate were observed in both groups. However, these improvements did not differ significantly between them. In addition, there were no differences in side effects between the groups. In conclusion, once a day administration of terazosin hydrochloride is as effective and safe as twice a day administration in patients with BPH
Beschreibung:	Date Completed 26.04.2001 Date Revised 21.11.2013 published: Print Citation Status MEDLINE
ISSN:	0018-1994