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01000naa a22002652 4500 |
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NLM111487919 |
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DE-627 |
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20231222155719.0 |
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tu |
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231222s2001 xx ||||| 00| ||eng c |
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|a pubmed24n0372.xml
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|a (DE-627)NLM111487919
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|a (NLM)11237552
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ellis, T M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Alterations in CD30(+) T cells in monoclonal gammopathy of undetermined significance
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| 264 |
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1 |
|c 2001
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 29.03.2001
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| 500 |
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|a Date Revised 16.11.2017
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2001 Academic Press.
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| 520 |
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|a Monoclonal gammopathy of unknown significance (MGUS) is a monoclonal B cell expansion characterized by high levels of circulating monoclonal antibody that affects 3% of individuals over the age of 70. Although this is considered benign, a high percentage of MGUS patients develop a debilitating peripheral autoimmune neuropathy and have a significantly increased risk for progression to multiple myeloma. Here we show that the relative numbers of the CD30(+) T cell subset and levels of CD30 expression are elevated in activated lymphocytes from normal aged individuals (> or =60 years) and in MGUS patients, when compared to younger controls. PBL from MGUS patients and age-matched controls produced comparable levels of IL-6 when activated with anti-CD3 plus IL-2, and costimulation with a soluble form of CD30 ligand (sCD30L/CD8alpha) augmented anti-CD3 inducible IL-6 production similarly in both groups. However, MGUS PBL also produced measurable IL-6 when activated with sCD30L/CD8alpha alone. This capability was associated with the unique presence of CD30(+) T cells in the peripheral blood of MGUS patients. Furthermore, a higher percentage of activated MGUS T cells express CD30 when activated by incubation with idiotype-expressing autologous serum (68 +/- 13) than those activated by anti-CD3 plus IL-2 (43 +/- 7). These results indicate that quantitative alterations in CD30(+) T cells accompany aging and MGUS and that these cells may contribute to the chronic activation of B cells though the production of IL-6
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a CD30 Ligand
|2 NLM
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| 650 |
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7 |
|a CD8 Antigens
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Ki-1 Antigen
|2 NLM
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a TNFSF8 protein, human
|2 NLM
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| 700 |
1 |
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|a Le, P T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a DeVries, G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stubbs, E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fisher, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bhoopalam, N
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 98(2001), 3 vom: 10. März, Seite 301-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:98
|g year:2001
|g number:3
|g day:10
|g month:03
|g pages:301-7
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 98
|j 2001
|e 3
|b 10
|c 03
|h 301-7
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