Adjuvant-induced improvement of glucose intolerance in type 2 diabetic KK-Ay mice through interleukin-1 and tumor necrosis factor-alpha

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 97(2000), 3 vom: 01. Dez., Seite 259-65
1. Verfasser:	Muto, G (VerfasserIn)
Weitere Verfasser:	Satoh, J, Muto, Y, Takahashi, K, Nakazawa, T, Sagara, M, Miyaguchi, S, Fukuzawa, M, Qiang, X, Sakata, Y, Takizawa, Y, Li, Y, Bando, S, Housai, T, Tamagawa, A, Toyota, T
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2000
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antibodies Interleukin-1 Tumor Necrosis Factor-alpha Freund's Adjuvant 9007-81-2

Beschreibung
Zusammenfassung:	Copyright 2000 Academic Press. We reported that administration of complete Freund's adjuvant (CFA) improved glucose tolerance test (GTT) results in obese diabetic KK-Ay mice. In this study, we investigated its mechanism. An injection with CFA remarkably improved GTT for more than a week in KK-Ay mice, although insulin response was not changed compared with saline controls. The hypoglycemic effect of insulin was significantly, but partially, potentiated in the CFA-treated mice compared with the controls, suggesting that CFA stimulated insulin-mediated and non-insulin-mediated glucose disposal. Improvement in the GTT with CFA was partially transferable to nontreated mice by peritoneal exudative cells, but not spleen or lymph node cells. Pretreatment with anti-interleukin (IL)-1 alpha and -1 beta antibodies or anti-tumor necrosis factor (TNF)-alpha antibody significantly abrogated the improvement in the GTT with CFA. The results indicate that CFA-induced improvement in glucose intolerance in KK-Ay mice was mediated at least by IL-1 and TNF-alpha
Beschreibung:	Date Completed 11.01.2001 Date Revised 15.11.2006 published: Print Citation Status MEDLINE
ISSN:	1521-7035