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01000naa a22002652 4500 |
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NLM110274849 |
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DE-627 |
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20231222153127.0 |
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tu |
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231222s2000 xx ||||| 00| ||eng c |
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|a pubmed24n0368.xml
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|a (DE-627)NLM110274849
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|a (NLM)11112364
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Serrano, D
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Characterization of the T cell receptor repertoire in patients with common variable immunodeficiency
|b oligoclonal expansion of CD8(+) T cells
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| 264 |
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|c 2000
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 11.01.2001
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|a Date Revised 16.11.2017
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2000 Academic Press.
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|a Common variable immunodeficiency is characterized by an impairment in antibody production of at least two immunoglobulin isotypes, and abnormalities of both B and T cells have also been described. In this study, a profound alteration of the T cell receptor repertoire was noted, especially in CD8(+) T cells, in CVID patients when compared to a control group. However, the higher number of oligoclonally expanded populations seen in the patient group was not dependent on age, whereas in the control group an age-related accumulation of these populations was noted. Expansion of CD8(+) CD28(-) T cells in these patients is strongly correlated with T cell receptor repertoire restriction. Furthermore, analysis of cytokine production showed a statistically significant increase in IFN-gamma secretion in the patient group. Lastly, CD94 and perforin were expressed at increased frequencies on CD8(+) T cells in the patient group when compared to the control group. We speculate that these findings support the concept that CD8(+) T cells may play an important regulatory role in CVID
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| 650 |
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|a Journal Article
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|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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|a CD28 Antigens
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Becker, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cunningham-Rundles, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mayer, L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 97(2000), 3 vom: 01. Dez., Seite 248-58
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:97
|g year:2000
|g number:3
|g day:01
|g month:12
|g pages:248-58
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 97
|j 2000
|e 3
|b 01
|c 12
|h 248-58
|