Glassy dynamics of protein folding
A coarse-grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent beta approximately 1...
| Veröffentlicht in: | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. - 1993. - 61(2000), 2 vom: 01. Feb., Seite R1040-3 |
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| Format: | Aufsatz |
| Sprache: | English |
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2000
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| Zugriff auf das übergeordnete Werk: | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Peptides |
| Zusammenfassung: | A coarse-grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent beta approximately 1/4, in agreement with the best experimental results. The time dependent correlation functions for fluctuations about the native state, computed in the Gaussian approximation for real proteins, have also been found to have the same functional form. Our results indicate that the energy landscape exhibits universal features over a very large range of energies and is relatively independent of the specific dynamics |
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| Beschreibung: | Date Completed 04.12.2000 Date Revised 28.07.2019 published: Print Citation Status MEDLINE |
| ISSN: | 1063-651X |