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231222s2000 xx ||||| 00| ||eng c |
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|a pubmed24n0365.xml
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|a (DE-627)NLM109464265
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|a (NLM)11027453
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Sun, J B
|e verfasserin
|4 aut
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|a Enhanced immunological tolerance against allograft rejection by oral administration of allogeneic antigen linked to cholera toxin B subunit
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| 264 |
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|c 2000
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 07.12.2000
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|a Date Revised 21.11.2008
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2000 Academic Press.
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|a A single oral intragastric administration of cholera toxin B subunit (CTB) conjugated to allogeneic thymocytes (ATC, 4 x 10(7) cells) under conditions allowing the CTB to bind the complex to GM1 ganglioside receptors was shown to be efficacious in inducing peripheral T cell tolerance associated with significant suppression of both primary and secondary accelerated rejection of heart allografts when tested in mice. Allogeneic in vivo delayed-type hypersensitivity (DTH), in vitro cytotoxicity responses, and mixed lymphocyte reactions (MLR) by T cells from mesenteric lymph nodes (MLN), popliteal lymph nodes (PLN), and spleen were significantly reduced in mice treated with the CTB-ATC conjugate, as were also the numbers of cells in these organs producing IL-2, IFN-gamma, or IL-4. In contrast, a marked increase in the production of IL-4 in Peyer's patches (PP) and of TGF-beta(1) in PLN was observed. The suppressive potential of T cells from PP and/or MLN after oral treatment with CTB-ATC was further evident by intraperitoneal transfer of such cells from CTB-ATC-treated animals to primed recipients, which led to marked suppression of both allogen-specific DTH and MLR responses. A critical role for PP in inducing peripheral tolerance after oral CTB-ATC treatment was indicated by the absence of tolerance induction in animals whose PP had been destroyed before treatment with CTB-ATC. The results indicate that the protection against allograft rejection by oral treatment with CTB-ATC is mediated by T cells and associated with a strong induction of IL-4 production at mucosal sites and TGF-beta(1) at the effector sites
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Adjuvants, Immunologic
|2 NLM
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|a Isoantigens
|2 NLM
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|a Tgfb1 protein, mouse
|2 NLM
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|a Transforming Growth Factor beta
|2 NLM
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|a Transforming Growth Factor beta1
|2 NLM
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| 650 |
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|a Interleukin-4
|2 NLM
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| 650 |
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|a 207137-56-2
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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|a Cholera Toxin
|2 NLM
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| 650 |
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|a 9012-63-9
|2 NLM
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| 700 |
1 |
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|a Li, B L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Czerkinsky, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holmgren, J
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 97(2000), 2 vom: 01. Nov., Seite 130-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:97
|g year:2000
|g number:2
|g day:01
|g month:11
|g pages:130-9
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|a GBV_NLM
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|d 97
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|h 130-9
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