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01000naa a22002652 4500 |
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NLM109464249 |
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DE-627 |
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20231222151407.0 |
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tu |
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231222s2000 xx ||||| 00| ||eng c |
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|a pubmed24n0365.xml
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|a (DE-627)NLM109464249
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|a (NLM)11027451
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Oliver, S J
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Immune stimulation in scleroderma patients treated with thalidomide
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| 264 |
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1 |
|c 2000
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.12.2000
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2000 Academic Press.
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|a Scleroderma (SSc) is a fibrosing connective tissue disease that is poorly responsive to any treatment, including immune suppression. SSc shares many characteristics with chronic graft-versus-host disease (GVHD). Because the immunomodulatory drug thalidomide has proven beneficial in chronic GVHD, we studied the immune response and clinical effects of thalidomide in SSc patients. We treated 11 SSc patients with thalidomide in an open label, dose escalating, 12 week study. Histologic comparison of skin biopsies showed changes in skin fibrosis and an increase in epidermal and dermal infiltrating CD8(+) T cells with thalidomide treatment. In thalidomide-treated SSc patients, plasma levels of IL-12 and TNF-alpha increased, while plasma IL-5 and IL-10 levels remained unchanged. These changes were associated with clinical effects, including dry skin, dermal edema, transient rashes, decreased gastroesophageal reflux symptoms, and healing of digital ulcers. When SSc PBMCs activated by anti-CD3 mAb were exposed to thalidomide, increases in both production of IL-2, IL-3, GM-CSF, and IFN-gamma and T cell expression of CD40L were observed. Thalidomide therefore appears to induce immune stimulation in SSc patients in association with clinical changes. However, it remains to be shown whether long-term enhancement of immune responses in SSc patients is clinically beneficial
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Adjuvants, Immunologic
|2 NLM
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| 650 |
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7 |
|a Hematopoietic Cell Growth Factors
|2 NLM
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| 650 |
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7 |
|a Thalidomide
|2 NLM
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| 650 |
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7 |
|a 4Z8R6ORS6L
|2 NLM
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| 700 |
1 |
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|a Moreira, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kaplan, G
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 97(2000), 2 vom: 01. Nov., Seite 109-20
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:97
|g year:2000
|g number:2
|g day:01
|g month:11
|g pages:109-20
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|a AR
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| 952 |
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|d 97
|j 2000
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|h 109-20
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