Endocrine therapy of stage D2 prostate cancer--comparison of drugs used for total androgen blockade
Patients with Stage D2 prostate cancer were treated with surgical or medical (LHRH analog) castration combined with either estrogen, chlormadinone acetate or flutamide as initial therapy. The effect of each medication was compared. The overall survival, cause-specific survival and relapse-free survi...
| Publié dans: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 46(2000), 1 vom: 29. Jan., Seite 9-14 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article |
| Langue: | Japanese |
| Publié: |
2000
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| Accès à la collection: | Hinyokika kiyo. Acta urologica Japonica |
| Sujets: | Clinical Trial Comparative Study Journal Article Androgen Antagonists Antineoplastic Agents, Hormonal Estrogens Triptorelin Pamoate 08AN7WA2G0 Chlormadinone Acetate 0SY050L61N plus... |
| Résumé: | Patients with Stage D2 prostate cancer were treated with surgical or medical (LHRH analog) castration combined with either estrogen, chlormadinone acetate or flutamide as initial therapy. The effect of each medication was compared. The overall survival, cause-specific survival and relapse-free survival were not different among the three medications. Patients given each medication were divided into two groups each according to grade, extent of diseases on bone metastases, and levels of tumor marker. Survivals of the corresponding two groups were compared with each other among different medications. No differences were revealed with any medication. There were no serious side effects in whole patients, except that grade 2 liver dysfunction was accompanied in 12% of flutamide-treated group. It is concluded that the three drugs used with castration did not make any difference in the survival of stage D2 patients, and differences between medications were seen in the frequency of side effects |
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| Description: | Date Completed 05.05.2000 Date Revised 30.11.2018 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |