|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM106201816 |
| 003 |
DE-627 |
| 005 |
20231222140331.0 |
| 007 |
tu |
| 008 |
231222s2000 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0354.xml
|
| 035 |
|
|
|a (DE-627)NLM106201816
|
| 035 |
|
|
|a (NLM)10692240
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a de Martino, M
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infection
|
| 264 |
|
1 |
|c 2000
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.04.2000
|
| 500 |
|
|
|a Date Revised 15.11.2006
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright 2000 Academic Press.
|
| 520 |
|
|
|a Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median; range 13-151) months] with human immunodeficiency virus-type 1 (HIV-1) perinatal infection and severe disease. Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS </= -2, compared to 22 children with height velocity SDS > -2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Insulin-Like Growth Factor Binding Protein 3
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-6
|2 NLM
|
| 650 |
|
7 |
|a Insulin-Like Growth Factor I
|2 NLM
|
| 650 |
|
7 |
|a 67763-96-6
|2 NLM
|
| 700 |
1 |
|
|a Galli, L
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chiarelli, F
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Verrotti, A
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rossi, M E
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bindi, G
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Galluzzi, F
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Salti, R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Vierucci, A
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 94(2000), 3 vom: 25. März, Seite 212-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:94
|g year:2000
|g number:3
|g day:25
|g month:03
|g pages:212-8
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 94
|j 2000
|e 3
|b 25
|c 03
|h 212-8
|