Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue

Copyright 1999 Academic Press.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 93(1999), 3 vom: 15. Dez., Seite 239-44
1. Verfasser: Schroeder, J R (VerfasserIn)
Weitere Verfasser: Saah, A J, Ambinder, R F, Martinez-Maza, O, Crabb Breen, E, Variakojis, D, Margolick, J B, Jacobson, L P, Rowe, D T, Hoover, D R
Format: Aufsatz
Sprache:English
Veröffentlicht: 1999
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Receptors, IgE
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100 1 |a Schroeder, J R  |e verfasserin  |4 aut 
245 1 0 |a Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue 
264 1 |c 1999 
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520 |a The cytokine soluble CD23 (sCD23) acts as a B cell growth factor and is associated with Epstein-Barr virus (EBV) infection. To elucidate the role sCD23 might play in the pathogenesis of AIDS-related non-Hodgkin's lymphoma (AIDS NHL), 101 AIDS NHL patients from the Multicenter AIDS Cohort Study were studied. Serum sCD23 within 18 months prior to lymphoma diagnosis was measured for all patients and EBV in tumor tissue was ascertained for 49 patients. Tumor morphology and primary site were verified from pathology reports and tumor specimens. Bivariate tests and multivariate regression were employed to determine whether serum sCD23 correlated with tumor EBV, morphology, and primary site. Higher levels of serum sCD23 were associated with the absence of tumor EBV and with small noncleaved cell morphology. Thus, the serum sCD23 level does not appear to be mediated by EBV in these patients, but could be related to a pathogenetic mechanism of small noncleaved cell lymphoma 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Research Support, U.S. Gov't, P.H.S. 
650 7 |a Receptors, IgE  |2 NLM 
700 1 |a Saah, A J  |e verfasserin  |4 aut 
700 1 |a Ambinder, R F  |e verfasserin  |4 aut 
700 1 |a Martinez-Maza, O  |e verfasserin  |4 aut 
700 1 |a Crabb Breen, E  |e verfasserin  |4 aut 
700 1 |a Variakojis, D  |e verfasserin  |4 aut 
700 1 |a Margolick, J B  |e verfasserin  |4 aut 
700 1 |a Jacobson, L P  |e verfasserin  |4 aut 
700 1 |a Rowe, D T  |e verfasserin  |4 aut 
700 1 |a Hoover, D R  |e verfasserin  |4 aut 
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