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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed25n0349.xml
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|a (DE-627)NLM104583231
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|a (NLM)10527691
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Han, S S
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53
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| 264 |
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|c 1999
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 23.11.1999
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| 500 |
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|a Date Revised 21.11.2013
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 1999 Academic Press.
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|a It has been well known that curcumin is a powerful inhibitor of proliferation of several tumor cells. However, the molecular basis of the anti-proliferative effect of curcumin has not been investigated in detail. In this paper, we present evidence to show that curcumin inhibited proliferation of a variety of B lymphoma cells. At low concentrations curcumin inhibited the proliferation of BKS-2, an immature B cell lymphoma, more effectively than that of normal B lymphocytes and caused the apoptosis of BKS-2 cells in a dose- and time-dependent manner. Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells. In addition, NF-kappaB binding activity was also downregulated almost completely by curcumin. Stimulation with CpG oligonucleotides or anti-CD40 overcame growth inhibition induced by low concentrations of curcumin. Our results suggest that curcumin caused the growth arrest and apoptosis of BKS-2 immature B cell lymphoma by downregulation of growth and survival promoting genes
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Bcl2l1 protein, mouse
|2 NLM
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| 650 |
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7 |
|a DNA-Binding Proteins
|2 NLM
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| 650 |
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|a Early Growth Response Protein 1
|2 NLM
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| 650 |
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|a Egr1 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Growth Inhibitors
|2 NLM
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| 650 |
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|a Immediate-Early Proteins
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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7 |
|a Proto-Oncogene Proteins c-bcl-2
|2 NLM
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| 650 |
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7 |
|a Proto-Oncogene Proteins c-myc
|2 NLM
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| 650 |
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7 |
|a Transcription Factors
|2 NLM
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| 650 |
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7 |
|a Tumor Suppressor Protein p53
|2 NLM
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| 650 |
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|a bcl-X Protein
|2 NLM
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| 650 |
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|a Curcumin
|2 NLM
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| 650 |
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7 |
|a IT942ZTH98
|2 NLM
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| 700 |
1 |
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|a Chung, S T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Robertson, D A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ranjan, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bondada, S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 93(1999), 2 vom: 01. Nov., Seite 152-61
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:93
|g year:1999
|g number:2
|g day:01
|g month:11
|g pages:152-61
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 93
|j 1999
|e 2
|b 01
|c 11
|h 152-61
|