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20250201134551.0 |
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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed25n0348.xml
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|a (DE-627)NLM104278994
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|a (NLM)10497011
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Falcini, F
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Reduction of bcl-2 in T cells during immunosuppressive therapy in patients with severe juvenile onset systemic lupus erythematosus
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| 264 |
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|c 1999
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.11.1999
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|a Date Revised 17.11.2004
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 1999 Academic Press.
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|a Overexpression of bcl-2 protein has been observed in the cytoplasm of T lymphocytes from adults with systemic lupus erythematosus (SLE). The aims of our study were to investigate the distribution of bcl-2 in T and B cells from patients affected with juvenile onset SLE (JSLE) and to monitor the modification of bcl-2 expression under immunosuppressive therapy. Thirty-two JSLE patients entered the study; 45 pathological and 16 healthy subjects were studied as controls. In SLE patients the disease activity was assessed using SLE disease activity index score. Bcl-2 expression was evaluated by cytofluorimetry. PCR analysis of t(14,18) translocation was performed from genomic DNA isolated from peripheral blood mononuclear cells. An increased bcl-2 expression both on cytoplasm and on cell surface of circulating T lymphocytes in JSLE patients with active disease was found. A variation, under pharmacological treatment, of protein expression during the course of the disease was observed. PCR analyses demonstrated that 14, 18 translocation was not associated with bcl-2 overexpression. Our data show a strong correlation between bcl-2 protein expression and disease activity and suggest an alteration of apoptotic regulation in JSLE patients
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| 650 |
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|a Journal Article
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| 650 |
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|a Immunosuppressive Agents
|2 NLM
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| 650 |
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|a Proto-Oncogene Proteins c-bcl-2
|2 NLM
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| 700 |
1 |
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|a Azzari, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gelli, V A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luchetti, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gabrielli, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Calzolari, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pignone, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Generini, S
|e verfasserin
|4 aut
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| 700 |
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|a Matucci Cerinic, M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 93(1999), 1 vom: 01. Okt., Seite 59-64
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:93
|g year:1999
|g number:1
|g day:01
|g month:10
|g pages:59-64
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| 912 |
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|d 93
|j 1999
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|h 59-64
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