Detection of low-frequency mutations in exon 8 of the TP53 gene by constant denaturant capillary electrophoresis (CDCE)

Detection of low-frequency mutations in exon 8 of the TP53 gene by constant denaturant capillary electrophoresis (CDCE)

We extended our development of the means to measure point mutations at the DNA level to the problem of detecting TP53 gene variants in the area around tumors where mutant fractions are expected to be as low as one mutant per 1000 wild-type (WT) sequences. We met this criterion by using the following...

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Bibliographische Detailangaben
Veröffentlicht in:BioTechniques. - 1988. - 27(1999), 1 vom: 01. Juli, Seite 128-34
1. Verfasser: Ekstrøm, P O (VerfasserIn)
Weitere Verfasser: Børresen-Dale, A L, Qvist, H, Giercksky, K E, Thilly, W G
Format: Aufsatz
Sprache:English
Veröffentlicht: 1999
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Neoplasm Proteins