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01000naa a22002652 4500 |
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NLM103025464 |
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DE-627 |
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20231222125505.0 |
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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed24n0344.xml
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|a (DE-627)NLM103025464
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|a (NLM)10370369
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rawlings, D J
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function
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| 264 |
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1 |
|c 1999
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 25.06.1999
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|a Date Revised 24.02.2022
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Genetic data support a role for Btk during the B lineage development transitions regulated by signaling through both the pre-B and the B cell antigen receptors. Dysregulated signaling at each of these transitions can result in failure of these cell populations to proliferate and subsequent cell death. Btk-dependent IP3 production is crucial for maintaining the sustained calcium signal in response to BCR engagement and is likely to regulate a subset of transcriptional events essential for B lineage growth or survival. Identification of these Btk-dependent signals will be important in understanding B cell activation, differentiation, and cell death. This information may lead to therapies specifically targeting these events in B cell autoimmunity or malignancy and provide a fuller understanding of the appropriate target populations and potential negative consequences of Btk gene therapy in XLA. Identification of Btk/Tec family kinases in an increasing number of vertebrate and invertebrate cell lineages suggests that the link between Btk and the PLC gamma/IP3/calcium signaling pathways may be broadly conserved
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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4 |
|a Review
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| 650 |
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7 |
|a Receptors, Antigen, B-Cell
|2 NLM
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| 650 |
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7 |
|a Protein-Tyrosine Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.1
|2 NLM
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| 650 |
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7 |
|a Agammaglobulinaemia Tyrosine Kinase
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.2
|2 NLM
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| 650 |
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7 |
|a BTK protein, human
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.2
|2 NLM
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| 650 |
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7 |
|a src-Family Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.2
|2 NLM
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 91(1999), 3 vom: 01. Juni, Seite 243-53
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:91
|g year:1999
|g number:3
|g day:01
|g month:06
|g pages:243-53
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| 912 |
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| 912 |
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|a AR
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| 952 |
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|d 91
|j 1999
|e 3
|b 01
|c 06
|h 243-53
|