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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed25n0339.xml
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|a (DE-627)NLM101519745
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|a (NLM)10219260
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Birmingham, D J
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effects of immune complex formation and complement activation on circulating platelets in the primate
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| 264 |
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|c 1999
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 17.05.1999
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| 500 |
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|a Date Revised 14.11.2007
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Primate platelets are different from rodent and rabbit platelets in that they do not express receptors for C3a or C5a or immune adherence receptors. This study assessed the effects of immune complex (IC)-induced complement activation on primate platelets in the circulation. Cynomolgus monkeys (CYN, N = 4) immunized to bovine gamma globulin (BGG) were infused with BGG over 5 min to induce acute intravascular IC formation and complement activation. The studies were carried out under normal complement conditions (N = 12), partial complement inhibition (CAB-2 treated, N = 3), or total complement inhibition (CVF treated, N = 1). Under normal complement conditions, BGG infusion increased C3a levels from undetectable to an average of 11.9 +/- 2.6 micrograms/ml. At this time, decreases occurring in both circulating neutrophils (85 +/- 6%) and monocytes (78 +/- 6%) were significantly greater than decreases in circulating platelets (13 +/- 3%, p < 0.001). Partial complement inhibition had an equivocal effect on the BGG-induced changes in circulating leukocytes, while total complement inhibition abrogated these changes. In contrast, platelet changes were unaffected by complement inhibition. We conclude that, compared to circulating leukocytes, circulating platelets are insensitive to intravascular complement activation induced by IC in the nonhuman primate. These results contrast with previous studies in rodents which demonstrate strong effects of IC-induced intravascular complement activation on both circulating neutrophils and platelets
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| 650 |
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|a Comparative Study
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Antigen-Antibody Complex
|2 NLM
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| 650 |
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|a gamma-Globulins
|2 NLM
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| 650 |
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|a Complement C3a
|2 NLM
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| 650 |
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7 |
|a 80295-42-7
|2 NLM
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| 700 |
1 |
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|a Hebert, L A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, X P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Higgins, P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yeh, C G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Creasey, A A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 91(1999), 1 vom: 16. Apr., Seite 99-105
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:91
|g year:1999
|g number:1
|g day:16
|g month:04
|g pages:99-105
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|h 99-105
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