Role of cytomegalovirus in the T cell changes seen in elderly individuals

Role of cytomegalovirus in the T cell changes seen in elderly individuals

Copyright 1999 Academic Press.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 90(1999), 2 vom: 19. Feb., Seite 213-9
1. Verfasser: Looney, R J (VerfasserIn)
Weitere Verfasser: Falsey, A, Campbell, D, Torres, A, Kolassa, J, Brower, C, McCann, R, Menegus, M, McCormick, K, Frampton, M, Hall, W, Abraham, G N
Format: Aufsatz
Sprache:English
Veröffentlicht: 1999
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, U.S. Gov't, P.H.S. Antibodies, Viral CD28 Antigens CD56 Antigen HLA-DR Antigens Immunoglobulin G Leukocyte Common Antigens EC 3.1.3.48
LEADER 01000naa a22002652 4500
001 NLM100141129
003 DE-627
005 20231222115526.0
007 tu
008 231222s1999 xx ||||| 00| ||eng c
028 5 2 |a pubmed24n0334.xml 
035 |a (DE-627)NLM100141129 
035 |a (NLM)10080833 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Looney, R J  |e verfasserin  |4 aut 
245 1 0 |a Role of cytomegalovirus in the T cell changes seen in elderly individuals 
264 1 |c 1999 
336 |a Text  |b txt  |2 rdacontent 
337 |a ohne Hilfsmittel zu benutzen  |b n  |2 rdamedia 
338 |a Band  |b nc  |2 rdacarrier 
500 |a Date Completed 29.03.1999 
500 |a Date Revised 16.11.2017 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Copyright 1999 Academic Press. 
520 |a The effect of prior cytomegalovirus (CMV) infection on the immune system was evaluated in young and elderly volunteers. Prevalence of IgG antibodies to CMV was higher in the elderly volunteers. In both age groups, there was a strong association with CMV seropositivity and increased number of CD28- CD4 or CD8 T cells, as well as with increased numbers of T cells expressing CD56 or DR. Although these changes have previously been reported to be age-related, they were independent of age when CMV serological status was taken into account. In contrast, both age group and CMV status were important determinants of the total number of T cells, the number of CD8 T cells, and the number of CD8 T cells expressing CD45RA or CD28. These findings indicate that prior infection with CMV, as reflected by CMV serological status, has important effects on T cell subsets and surface markers and must be considered whenever evaluating age-related changes in immunological parameters 
650 4 |a Journal Article 
650 4 |a Research Support, U.S. Gov't, P.H.S. 
650 7 |a Antibodies, Viral  |2 NLM 
650 7 |a CD28 Antigens  |2 NLM 
650 7 |a CD56 Antigen  |2 NLM 
650 7 |a HLA-DR Antigens  |2 NLM 
650 7 |a Immunoglobulin G  |2 NLM 
650 7 |a Leukocyte Common Antigens  |2 NLM 
650 7 |a EC 3.1.3.48  |2 NLM 
700 1 |a Falsey, A  |e verfasserin  |4 aut 
700 1 |a Campbell, D  |e verfasserin  |4 aut 
700 1 |a Torres, A  |e verfasserin  |4 aut 
700 1 |a Kolassa, J  |e verfasserin  |4 aut 
700 1 |a Brower, C  |e verfasserin  |4 aut 
700 1 |a McCann, R  |e verfasserin  |4 aut 
700 1 |a Menegus, M  |e verfasserin  |4 aut 
700 1 |a McCormick, K  |e verfasserin  |4 aut 
700 1 |a Frampton, M  |e verfasserin  |4 aut 
700 1 |a Hall, W  |e verfasserin  |4 aut 
700 1 |a Abraham, G N  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 90(1999), 2 vom: 19. Feb., Seite 213-9  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:90  |g year:1999  |g number:2  |g day:19  |g month:02  |g pages:213-9 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 90  |j 1999  |e 2  |b 19  |c 02  |h 213-9