|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM100093000 |
| 003 |
DE-627 |
| 005 |
20250201034206.0 |
| 007 |
tu |
| 008 |
231222s1999 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed25n0334.xml
|
| 035 |
|
|
|a (DE-627)NLM100093000
|
| 035 |
|
|
|a (NLM)10075869
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Alim, M A
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Structural relationship of lambda-type light chains with AL amyloidosis
|
| 264 |
|
1 |
|c 1999
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 13.04.1999
|
| 500 |
|
|
|a Date Revised 15.11.2006
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright 1999 Academic Press.
|
| 520 |
|
|
|a Three human amyloidogenic Bence Jones proteins, NIG76 VlambdaII, NIG204 VlambdaI, and NIG250 VlambdaV, were characterized. In a comparative study, three amino acids, Ser-25a, Thr-68, and Val-95, were found to be common to amyloidogenic proteins of the VlambdaII subgroup. NIG204 had an insertion of Pro residue following position 30 (30a). Proteins having an insertion at this position are invariantly amyloidogenic. NIG250 had a characteristic VlambdaV VL domain, with Mcg+ and KERN+ CL domain isotypes. Following the protein DEL, this is the second example of this subgroup. No common residue is found in the other subgroup proteins but unique substitutions do occur. It would seem that any substitution that causes an alteration in the protein conformation may lead to its being more prone to association with the amyloid processes
|
| 650 |
|
4 |
|a Comparative Study
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Immunoglobulin Light Chains
|2 NLM
|
| 650 |
|
7 |
|a Immunoglobulin Variable Region
|2 NLM
|
| 650 |
|
7 |
|a Bence Jones Protein
|2 NLM
|
| 650 |
|
7 |
|a 9006-99-9
|2 NLM
|
| 700 |
1 |
|
|a Yamaki, S
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hossain, M S
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Takeda, K
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yamagata, F
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Takashi, I
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shinoda, T
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 90(1999), 3 vom: 01. März, Seite 399-403
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
|
| 773 |
1 |
8 |
|g volume:90
|g year:1999
|g number:3
|g day:01
|g month:03
|g pages:399-403
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 90
|j 1999
|e 3
|b 01
|c 03
|h 399-403
|