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20250201004654.0 |
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231222s1998 xx ||||| 00| ||eng c |
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|a pubmed25n0329.xml
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|a (DE-627)NLM098558455
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|a (NLM)9920680
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Lancashire, C
|e verfasserin
|4 aut
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| 245 |
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|a Apolipoprotein E antibodies affect the retention of passive avoidance memory in the chick
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| 264 |
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|c 1998
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 13.04.1999
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|a Date Revised 16.03.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were injected intracerebrally with anti-ApoE. Immunofluorescence staining demonstrated the presence of the antibody bound to the neuropil, close to the injection site and adjacent to the ventricle, with a residence time in the brain of up to 30 min. Chicks that were injected 30 min pre-training or just post-training with 5 micrograms/hemisphere of the antibody learned the task, but were amnesic when tested at 30 min or at subsequent times up to 24 hr post-training. When tested at 24 hr, birds injected 5.5 hr post-training showed unimpaired retention. Birds injected with 5 micrograms/hemisphere of anti-ApoA-I (which has a brain distribution similar to that of anti-ApoE) at 30 min pretraining showed no amnesia, indicating the specificity of the effect to the ApoE. Possible mechanisms for this effect are discussed
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Antibodies
|2 NLM
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| 650 |
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7 |
|a Apolipoprotein A-I
|2 NLM
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| 650 |
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7 |
|a Apolipoproteins E
|2 NLM
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| 700 |
1 |
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|a Mileusnic, R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rose, S P
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Neural plasticity
|d 1998
|g 6(1998), 3 vom: 01. Juli, Seite 29-40
|w (DE-627)NLM098558390
|x 2090-5904
|7 nnns
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| 773 |
1 |
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|g volume:6
|g year:1998
|g number:3
|g day:01
|g month:07
|g pages:29-40
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| 912 |
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_21
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 6
|j 1998
|e 3
|b 01
|c 07
|h 29-40
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