Overexpression of human DNA topoisomerase II alpha by fusion to enhanced green fluorescent protein

DNA topoisomerase (topo) II alpha is a major target for many anticancer agents. However, progress towards understanding how these agents interact with this enzyme in human cells and how resistance to these agents arises is greatly impeded by difficulties in expressing this gene. Here, we report on a...

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Bibliographische Detailangaben
Veröffentlicht in:BioTechniques. - 1991. - 25(1998), 6 vom: 04. Dez., Seite 1052-7
1. Verfasser: Mo, Y Y (VerfasserIn)
Weitere Verfasser: Ameiss, K A, Beck, W T
Format: Aufsatz
Sprache:English
Veröffentlicht: 1998
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Enzyme Inhibitors Indicators and Reagents Luminescent Proteins RNA, Messenger Recombinant Fusion Proteins Topoisomerase II Inhibitors Green Fluorescent Proteins mehr... 147336-22-9 Teniposide 957E6438QA DNA Topoisomerases, Type II EC 5.99.1.3