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231222s1998 xx ||||| 00| ||jpn c |
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|a pubmed25n0324.xml
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|a (DE-627)NLM097214531
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|a (NLM)9783192
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a jpn
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| 100 |
1 |
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|a Ueki, O
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Clinical efficacy and reduction effect on prostatic volume of chlormadinone acetate combined with tamsulosin hydrochloride in benign prostatic hyperplasia patients insufficiently treated with tamsulosin hydrochloride only
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| 264 |
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|c 1998
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 04.11.1998
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|a Date Revised 01.12.2018
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| 500 |
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|a published: Print
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|a Citation Status MEDLINE
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|a Alpha adrenergic blocker has become the first choice in the medical treatment of benign prostatic hyperplasia (BPH). The efficacy of alpha adrenergic blocker has been suggested to be related to the prostatic tissue components, and to be ineffective in treating the clinical symptoms caused by BPH in some cases. The efficacy and prostate reduction of an anti-androgenic agent, chlormadinone acetate, combined with alpha adrenergic blocker, tamsulosin hydrochloride, were evaluated using 40-BPH patients insufficiently treated with tamsulosin hydrochloride alone. Fifty mg of chlormadinone acetate and 0.2 mg of tamsulosin hydrochloride were administered orally once a day for 16 weeks to patients with a prostate subjective symptoms score, I-PSS, of greater than 13 or a peak flow rate of less than 12 ml/s, even after the treatment with 0.2 mg of tamsulosin hydrochloride alone for more than four weeks. Total I-PSS decreased significantly after four weeks. The total irritative symptom score did not change for 16 weeks, but the total obstructive symptom score decreased significantly, as did the total I-PSS. In objective data, the estimated volume of both total prostate and the transition zone on transrectal ultrasonogram decreased significantly at the end of the treatment, and the peak flow rate decreased significantly after 12 weeks. These findings suggest that the addition of chlormadinone acetate may be a reasonable alternative in the treatment of BPH patients responding insufficiently to tamsulosin hydrochloride alone, and that combination therapy using chlormadinone acetate and tamsulosin hydrochloride may be useful for BPH patients with serious obstructive symptoms
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Adrenergic alpha-Antagonists
|2 NLM
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|a Delayed-Action Preparations
|2 NLM
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| 650 |
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7 |
|a Progesterone Congeners
|2 NLM
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| 650 |
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|a Sulfonamides
|2 NLM
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| 650 |
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7 |
|a Chlormadinone Acetate
|2 NLM
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| 650 |
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7 |
|a 0SY050L61N
|2 NLM
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| 650 |
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7 |
|a Tamsulosin
|2 NLM
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| 650 |
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7 |
|a G3P28OML5I
|2 NLM
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| 700 |
1 |
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|a Kawaguchi, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Katsumi, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Murayama, K
|e verfasserin
|4 aut
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|a Kameda, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nishino, A
|e verfasserin
|4 aut
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|a Sakai, A
|e verfasserin
|4 aut
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| 700 |
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|a Haginaka, T
|e verfasserin
|4 aut
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| 700 |
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|a Miyazaki, K
|e verfasserin
|4 aut
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|a Asari, T
|e verfasserin
|4 aut
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| 700 |
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|a Egawa, M
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 44(1998), 8 vom: 25. Aug., Seite 565-73
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
8 |
|g volume:44
|g year:1998
|g number:8
|g day:25
|g month:08
|g pages:565-73
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| 952 |
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|d 44
|j 1998
|e 8
|b 25
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|h 565-73
|