Fleroxacin treatment for acute uncomplicated cystitis in women comparison of 3-day and 7-day therapy

Fleroxacin treatment for acute uncomplicated cystitis in women : comparison of 3-day and 7-day therapy

The clinical efficacy of fleroxacin (FLRX), a new fluoroquinolone, for acute uncomplicated cystitis (AUC) in women was assessed. Two regimens, 3-day and 7-day courses of FLRX, 200 mg once a day, were compared. Clinical and bacteriological efficacy were evaluated after the therapy, and recurrence rat...

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Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 44(1998), 6 vom: 14. Juni, Seite 431-6
1. Verfasser: Ishihara, S (VerfasserIn)
Weitere Verfasser: Ban, Y, Kawada, Y, Ito, S, Ito, Y, Doi, T, Nezasa, S, Fujihiro, S, Yamaha, M, Ito, F, Iwata, H, Hasegawa, Y, Ueno, K, Shinoda, I, Taniguchi, M, Minoshima, K, Takeuchi, T, Sakai, S, Uno, H, Koide, T
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1998
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Clinical Trial Comparative Study English Abstract Journal Article Anti-Infective Agents Fleroxacin N804LDH51K
Beschreibung
Zusammenfassung:The clinical efficacy of fleroxacin (FLRX), a new fluoroquinolone, for acute uncomplicated cystitis (AUC) in women was assessed. Two regimens, 3-day and 7-day courses of FLRX, 200 mg once a day, were compared. Clinical and bacteriological efficacy were evaluated after the therapy, and recurrence rate was evaluated 1 week and 4 weeks after termination of the therapy. Of 136 registered subjects, 35 in the 3-day group and 47 in the 7-day group were evaluated. According to the criteria of Japanese UTI Committee (3rd edition), the rate of excellent results was significantly higher in the 7-day group (78.9%) than in the 3-day group (48.6%), but the overall clinical efficacy rate was similar being 100% and 97.9%, respectively. Although no recurrence was seen 1 week after the therapy in either group, recurrence was seen in 14.3% and 7.4% of the cases in the 3-day and 7-day groups, respectively, 4 weeks after the therapy. Adverse reactions were observed in 2 and 3 cases in the 3-day and 7-day groups, respectively. Both 3-day and 7-day regimens of FLRX treatment showed good efficacy. Although the 7-day treatment was superior to the 3-day treatment as to high rate of excellent results and low rate of recurrence, the 3-day treatment was concluded to be sufficient for AUC
Beschreibung:Date Completed 15.09.1998
Date Revised 21.11.2013
published: Print
Citation Status MEDLINE
ISSN:0018-1994