Free/total ratio of prostate-specific antigen (PSA) for prostate cancer detection in patients with gray zone PSA level
Thirty seven patients complaining of voiding disturbance who showed gray zone total prostate-specific antigen (t-PSA) level (upper limit of normal approximately 10 ng/ml) but did not reveal apparent cancerous findings in the prostate were examined for free PSA (f-PSA) and prostate volume. According...
| Publié dans: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 43(1997), 12 vom: 06. Dez., Seite 855-60 |
|---|---|
| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article |
| Langue: | Japanese |
| Publié: |
1997
|
| Accès à la collection: | Hinyokika kiyo. Acta urologica Japonica |
| Sujets: | Clinical Trial English Abstract Journal Article Biomarkers, Tumor Reagent Kits, Diagnostic Prostate-Specific Antigen EC 3.4.21.77 |
| Résumé: | Thirty seven patients complaining of voiding disturbance who showed gray zone total prostate-specific antigen (t-PSA) level (upper limit of normal approximately 10 ng/ml) but did not reveal apparent cancerous findings in the prostate were examined for free PSA (f-PSA) and prostate volume. According to histological diagnosis, 9 were cancer cases and the other 28 were non-cancer cases. The free/total (F/T) ratio was 0.10 and 0.16 in the cancer and non-cancer groups, respectively (t-PSA; DPC kit, p = 0.03). The t-PSA (DPC and Dinabott kits), f-PSA and PSA density alone did not distinguish these two groups. For diagnosis of cancer, the ratio seemed to be F/T, the most reliable followed by PSA density and t-PSA. When using a 13% F/T, the sensitivity and specificity for cancer detection were 88.9 and 70.8%, respectively. t-PSA measured with the Dinabott kit, showed a similar tendency except that the F/T ratio showed a slight variation. Prostate volume and patient age influenced the F/T slightly, but these factors may not impair the usefulness of F/T |
|---|---|
| Description: | Date Completed 17.04.1998 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |