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|a jpn
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1 |
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|a Togashi, M
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Three cases of lung metastases of renal cell carcinoma treated with a combination of interferon-alpha, 5-fluorouracil and leucovorin
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|c 1996
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
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| 338 |
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|a Date Completed 20.08.1996
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a Three patients with lung metastases of renal cell carcinoma (RCC) were treated with a combination of interferon-alpha, leucovorin and 5-fluorouracil. All patients were male between 60 and 66 years and had been treated by nephrectomy prior to the combination therapy. Interferon-alpha was administered at the dose of 9 x 10(6) IU intramuscularly 3 times/week, leucovorin at 30 mg/m2 per day intravenously (day 1 to 5) and 5-fluorouracil at 500 mg/m2 daily by continuous infusion intravenously (day 1 to 5) followed by weekly bolus therapy. One patient achieved complete response for 17 months and the other two achieved stable disease for 6 and 16 months. Side effects related to this therapy were diarrhea, stomatitis, alopecia, leucocytopenia and thrombocytopenia. Grade 3 stomatitis occurred after the continuous administration of 5-fluorouracil in one patient; he recovered by discontinuation of 5-fluorouracil. Combination therapy with interferon-alpha, leucovolin and 5-fluorouracil might be effective for the treatment of lung metastases of RCC
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|a Case Reports
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|a English Abstract
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|a Journal Article
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| 650 |
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|a Interferon-alpha
|2 NLM
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| 650 |
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|a Leucovorin
|2 NLM
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| 650 |
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7 |
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| 650 |
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|a Fluorouracil
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| 650 |
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| 700 |
1 |
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|a Tabata, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hirakawa, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ohashi, N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sindoh, J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hirano, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Demura, T
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 42(1996), 1 vom: 02. Jan., Seite 43-5
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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