Clinical evaluation of Augpenin (clavulanic acid-ticarcillin) in urinary tract infections especially against beta-lactamase producing strains

Clinical evaluation of Augpenin (clavulanic acid-ticarcillin) in urinary tract infections : especially against beta-lactamase producing strains

Augpenin contains ticarcillin (TIPC) and clavulanic acid (CVA), at a ratio of 15:1. The beta-lactamase inhibitor, CVA, has been added to protect the TIPC from inactivation by beta-lactamase. To investigate the drug efficacy and safety against urinary tract infections (UTI), Augpenin was administered...

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Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 39(1993), 8 vom: 15. Aug., Seite 777-82
1. Verfasser: Shiono, A (VerfasserIn)
Weitere Verfasser: Kurihara, J, Hayashi, M, Suzuki, T, Imai, K, Yamanaka, H, Takezawa, Y, Kiren, H, Okabe, K, Tomaru, Y
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1993
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:English Abstract Journal Article Clavulanic Acids beta-Lactamase Inhibitors Clavulanic Acid 23521W1S24 beta-Lactamases EC 3.5.2.6 Ticarcillin F93UJX4SWT
Beschreibung
Zusammenfassung:Augpenin contains ticarcillin (TIPC) and clavulanic acid (CVA), at a ratio of 15:1. The beta-lactamase inhibitor, CVA, has been added to protect the TIPC from inactivation by beta-lactamase. To investigate the drug efficacy and safety against urinary tract infections (UTI), Augpenin was administered to 33 patients with chronic complicated UTI and 7 patients with acute pyelonephritis. Thirty two cases were evaluable by the UTI criteria. Excellent results were obtained in 6 of the cases of acute pyelonephritis, and moderate results in 1 case, with an overall effectiveness rate of 100%. Excellent results were obtained in 14 of the cases of chronic complicated UTI, moderate results in 9 cases, and poor results in 2 cases, with an overall effectiveness rate of 92%. No adverse reactions were noted, but a transient elevation of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase levels was observed in 2 cases
Beschreibung:Date Completed 20.10.1993
Date Revised 20.11.2014
published: Print
Citation Status MEDLINE
ISSN:0018-1994