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01000naa a22002652 4500 |
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NLM079177018 |
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DE-627 |
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20231222041610.0 |
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tu |
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231222s1994 xx ||||| 00| ||jpn c |
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2 |
|a pubmed24n0264.xml
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|a (DE-627)NLM079177018
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| 035 |
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|a (NLM)7942364
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a jpn
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| 100 |
1 |
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|a Noguchi, S
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a M-VAC chemotherapy for advanced urothelial cancer--side effects and their management
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| 264 |
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1 |
|c 1994
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 04.11.1994
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| 500 |
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|a Date Revised 21.11.2013
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Since the M-VAC (methotrexate, vinblastine, doxorubicin, cisplatin) regimen was reported by Sternberg in 1985, it has been widely accepted for the treatment of metastatic transitional cell carcinoma. This regimen has a significantly high response rate, but bone marrow suppression and gastrointestinal (GI) symptoms are inevitable. To complete this M-VAC regimen, preventive therapy for side effects is necessary. From November 1986 to March 1993, a total of 72 patients were admitted and received M-VAC therapy at our hospital. All of them had metastatic or invasive transitional cell carcinoma and they received a total of 163 complete courses of M-VAC therapy. We examined the side effects of this M-VAC regimen, and evaluated the effectiveness of colony-stimulating factor for prevention of granulocytopenia or granisetron for prevention of GI symptoms. Twenty-three patients (39 courses) were given recombinant colony-stimulating factor. This cytokine prevented the nadir of neutropenia and shortened the period to reach the nadir and period that the neutrophil count was below 1,000/mm3. Twelve patients (26 courses) were given granisetron, with significant reduction of the incidence of GI symptoms. These findings suggest that M-VAC therapy is effective and safe when used in combination with these drugs
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| 650 |
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4 |
|a Clinical Trial
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Colony-Stimulating Factors
|2 NLM
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| 650 |
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7 |
|a Recombinant Proteins
|2 NLM
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| 650 |
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7 |
|a Vinblastine
|2 NLM
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| 650 |
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7 |
|a 5V9KLZ54CY
|2 NLM
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| 650 |
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7 |
|a Doxorubicin
|2 NLM
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| 650 |
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7 |
|a 80168379AG
|2 NLM
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| 650 |
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7 |
|a Cisplatin
|2 NLM
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| 650 |
|
7 |
|a Q20Q21Q62J
|2 NLM
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| 650 |
|
7 |
|a Granisetron
|2 NLM
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| 650 |
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7 |
|a WZG3J2MCOL
|2 NLM
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| 650 |
|
7 |
|a Methotrexate
|2 NLM
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| 650 |
|
7 |
|a YL5FZ2Y5U1
|2 NLM
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| 700 |
1 |
|
|a Kubota, Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shuin, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Masuda, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Misaki, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kondoh, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sakuramoto, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hosaka, M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 40(1994), 8 vom: 01. Aug., Seite 677-82
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
8 |
|g volume:40
|g year:1994
|g number:8
|g day:01
|g month:08
|g pages:677-82
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_20
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| 912 |
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|a GBV_ILN_22
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| 912 |
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|a GBV_ILN_40
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| 912 |
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| 912 |
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|a GBV_ILN_72
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| 912 |
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|a GBV_ILN_120
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| 912 |
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|a GBV_ILN_350
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| 912 |
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|a GBV_ILN_2001
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| 912 |
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|a GBV_ILN_2003
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| 912 |
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|a GBV_ILN_2005
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| 912 |
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|a GBV_ILN_2006
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| 912 |
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|a GBV_ILN_2008
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| 912 |
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|a GBV_ILN_2010
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| 912 |
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|a GBV_ILN_2012
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| 912 |
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|a GBV_ILN_2018
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| 951 |
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|a AR
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| 952 |
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|d 40
|j 1994
|e 8
|b 01
|c 08
|h 677-82
|