Lomefloxacin concentration in human prostatic tissue following 3-day administration
The penetration of Lomefloxacin (LFLX) into the prostatic tissue and the serum were examined. Forty four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate (TUR-P) were entered in this study. LFLX was administered orally in a dose of 200 mg three times da...
| Veröffentlicht in: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 39(1993), 1 vom: 15. Jan., Seite 97-9 |
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| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | Japanese |
| Veröffentlicht: |
1993
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| Zugriff auf das übergeordnete Werk: | Hinyokika kiyo. Acta urologica Japonica |
| Schlagworte: | English Abstract Journal Article Anti-Infective Agents Fluoroquinolones Quinolones lomefloxacin L6BR2WJD8V |
| Zusammenfassung: | The penetration of Lomefloxacin (LFLX) into the prostatic tissue and the serum were examined. Forty four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate (TUR-P) were entered in this study. LFLX was administered orally in a dose of 200 mg three times daily for three days preoperatively. The blood samples were taken simultaneously at the time of the tissue sampling. The patients were divided into groups 1 and 2. In group 1 (seventeen patients), the tissue sampling was done about 17 hours after the final drug administration. The mean concentration of LFLX was 3.31 +/- 1.16 micrograms/g in the prostatic tissue and 1.70 +/- 0.56 micrograms/ml in the serum. In group 2 (twenty seven patients), tissue sampling was done 5.5 hours after the final drug administration. The mean concentration of LFLX was 5.70 +/- 2.28 micrograms/g in the prostatic tissue and 2.93 +/- 1.14 micrograms/ml in the serum |
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| Beschreibung: | Date Completed 23.04.1993 Date Revised 15.11.2012 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |