Concentrations of new quinolone agents in serum and prostate tissue

Twenty five patients with benign prostate hypertrophy were administered ofloxacin (OFLX) simultaneously with norfloxacin (NFLX) in 6 patients, ciprofloxacin (CPFX) in 10, tosfloxacin (TFLX) in 5 and enoxacin (ENX) in 4 patients. The dose of these new quinolones was 100 mg (except 150 mg of TFLX). Th...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 40(1994), 5 vom: 08. Mai, Seite 401-6
1. Verfasser: Imai, K (VerfasserIn)
Weitere Verfasser: Suzuki, K, Yamanaka, H, Makino, T, Yazima, H, Takezawa, Y, Kitaura, K, Shiono, A, Sato, J, Kato, N
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1994
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:English Abstract Journal Article 4-Quinolones Anti-Infective Agents
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520 |a Twenty five patients with benign prostate hypertrophy were administered ofloxacin (OFLX) simultaneously with norfloxacin (NFLX) in 6 patients, ciprofloxacin (CPFX) in 10, tosfloxacin (TFLX) in 5 and enoxacin (ENX) in 4 patients. The dose of these new quinolones was 100 mg (except 150 mg of TFLX). Their concentrations in the serum and the prostate tissue were measured by high performance liquid chromatography (HPLC). The serum concentration of OFLX was significantly higher than that of NFLX, CPFX, TFLX or ENX. The prostate tissue concentration of OFLX was significantly higher than that of CPFX or TFLX. The ratio of tissue versus serum concentration of each new quinolone agent was not significantly different. The high OFLX tissue concentration appeared to be caused by the high serum concentration 
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700 1 |a Yamanaka, H  |e verfasserin  |4 aut 
700 1 |a Makino, T  |e verfasserin  |4 aut 
700 1 |a Yazima, H  |e verfasserin  |4 aut 
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700 1 |a Kitaura, K  |e verfasserin  |4 aut 
700 1 |a Shiono, A  |e verfasserin  |4 aut 
700 1 |a Sato, J  |e verfasserin  |4 aut 
700 1 |a Kato, N  |e verfasserin  |4 aut 
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