Bioavailability of aspirin in the presence of dextropropoxyphene/paracetamol combination

The effect of 2 doses of a combination analgesic preparation (each dose containing 65 mg dextropropoxyphene hydrochloride and 650 mg paracetamol) upon plasma salicylate concentration after a single dose of soluble aspirin (1.2 g) or enteric-coated aspirin (1.2 g) was examined in 6 normal volunteers...

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Bibliographische Detailangaben
Veröffentlicht in:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 2(1981), 8 vom: 16., Seite 543-6
1. Verfasser: Hemming, J D (VerfasserIn)
Weitere Verfasser: Bird, H A, Pickup, M E, Saunders, A, Lowe, J R, Dixon, J S
Format: Aufsatz
Sprache:English
Veröffentlicht: 1981
Zugriff auf das übergeordnete Werk:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
Schlagworte:Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Drug Combinations Acetaminophen 362O9ITL9D acetaminophen, dextropropoxyphene, drug combination 39400-85-6 Aspirin mehr... R16CO5Y76E Dextropropoxyphene S2F83W92TK
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245 1 0 |a Bioavailability of aspirin in the presence of dextropropoxyphene/paracetamol combination 
264 1 |c 1981 
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500 |a Date Completed 25.09.1981 
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500 |a published: Print 
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520 |a The effect of 2 doses of a combination analgesic preparation (each dose containing 65 mg dextropropoxyphene hydrochloride and 650 mg paracetamol) upon plasma salicylate concentration after a single dose of soluble aspirin (1.2 g) or enteric-coated aspirin (1.2 g) was examined in 6 normal volunteers and compared with the effect of placebo. The dextropropoxyphene/paracetamol caused no reduction in the plasma salicylate level after absorption of soluble aspirin compared with placebo and, although a reduction in plasma salicylate was seen after enteric-coated aspirin in a single subject, this may reflect erratic absorption rather than a drug interaction 
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650 7 |a Aspirin  |2 NLM 
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700 1 |a Bird, H A  |e verfasserin  |4 aut 
700 1 |a Pickup, M E  |e verfasserin  |4 aut 
700 1 |a Saunders, A  |e verfasserin  |4 aut 
700 1 |a Lowe, J R  |e verfasserin  |4 aut 
700 1 |a Dixon, J S  |e verfasserin  |4 aut 
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