Effect of pentoxifylline on platelet aggregation

The effect of various concentrations of pentoxifylline, a methylxanthine, on platelet aggregation was evaluated in vitro by Born's method. The study was performed on platelet-rich plasma obtained from two series of clinically healthy subjects: in the first, pentoxifylline was added to platelet-...

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Bibliographische Detailangaben
Veröffentlicht in:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 2(1981), 8 vom: 16., Seite 532-8
1. Verfasser: Nenci, G G (VerfasserIn)
Weitere Verfasser: Gresele, P, Agnelli, G, Ballatori, E
Format: Aufsatz
Sprache:English
Veröffentlicht: 1981
Zugriff auf das übergeordnete Werk:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Adenosine Diphosphate 61D2G4IYVH Theobromine OBD445WZ5P Pentoxifylline SD6QCT3TSU Epinephrine YKH834O4BH
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245 1 0 |a Effect of pentoxifylline on platelet aggregation 
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520 |a The effect of various concentrations of pentoxifylline, a methylxanthine, on platelet aggregation was evaluated in vitro by Born's method. The study was performed on platelet-rich plasma obtained from two series of clinically healthy subjects: in the first, pentoxifylline was added to platelet-rich plasma just before ADP or epinephrine; in the second, pentoxifylline was incubated with platelet-rich plasma for 150 minutes at 37 degrees C before testing. Statistical analysis of the results demonstrates that pentoxifylline exerts a dose-dependent inhibiting action on platelet aggregation, particularly when epinephrine is chosen as the aggregating agent, and that the pre-incubation of pentoxifylline with blood platelets greatly enhances its inhibitory effect 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Agnelli, G  |e verfasserin  |4 aut 
700 1 |a Ballatori, E  |e verfasserin  |4 aut 
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